Simple blood test could reveal hidden depression

Currently, doctors diagnose depression based on what patients report about their feelings and behavior. While lab tests can rule out other illnesses, there is no biological test that can confirm depression or identify it early.

Researchers focused on monocytes, a type of white blood cell involved in the body’s immune response. By analyzing blood samples from 440 women, both with and without HIV, they found that faster aging in these cells was closely linked to emotional and cognitive symptoms of depression. These included hopelessness, loss of pleasure, and feelings of failure.

Notably, the link was not seen with physical symptoms such as fatigue or appetite changes. This suggests the test may be particularly useful in identifying the less visible emotional side of depression, which can vary widely between individuals.

The findings also stood out in people living with HIV, who often experience physical symptoms that can overlap with depression, making diagnosis more difficult. The study indicates that biological changes in immune cells may help separate mental health symptoms from those caused by chronic illness.

Scientists measured biological aging using tools known as epigenetic clocks, which track changes in DNA over time. One clock focused specifically on monocytes, while another looked at multiple cell types. Only the monocyte-based measure showed a clear connection to depression symptoms.

Although the research is still at an early stage, experts say it could lead to earlier and more accurate diagnosis, as well as more personalized treatment in the future.

Earlier, Qazinform News Agency reported that a simple finger prick could change how Alzheimer’s is diagnosed.